Thalidomide, propargyl

Name: Thalidomide, propargyl
Brand: Tocris Bioscience
SKU: 6685

Tocris Bioscience, part of Bio-Techne | Catalog # 6685

COA / SDS

Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs

Key Product Details

Description:	Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs
Chemical Name:	2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione
Purity:	≥95% (HPLC)
Molecular Weight:	312.28

View Full Technical Details for Thalidomide, propargyl

Technical Data
Citations

Biological Activity for Thalidomide, propargyl

Thalidomide, propargyl is a click-activated Thalidomide (Cat.No. 0652); can be used as a precursor to a PROTAC^® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with an alkyne functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Thalidomide, propargyl

M. Wt	312.28
Formula	C₁₆H₁₂N₂O₅
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2098487-39-7
PubChem ID	132118478
InChi Key	NOGQTNDSZFYNTM-UHFFFAOYSA-N
Smiles	O=C1N(C(C2=C(C=CC=C12)OCC#C)=O)C3CCC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Thalidomide, propargyl

References are publications that support the biological activity of the product.

Wurz A "click chemistry platform" for the rapid rynthesis of bispecific molecules for inducing protein degradation. J.Med.Chem. 2018 PMID: 28378579