THIQ

Tocris Bioscience, part of Bio-Techne | Catalog # 3032

(1)

Citations (15)

COA / SDS

Potent and selective MC4 receptor agonist

Key Product Details

Chemical Name:	N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-trazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
Purity:	≥95%
Molecular Weight:	589.17 kDa

View Full Technical Details for THIQ

Technical Data
Citations / Reviews (1)

Biological Activity for THIQ

THIQ is a potent and selective melanocortin 4 (MC₄) receptor agonist (IC₅₀ values are 1.2, 761 and 2067 nM for human MC₄, MC₃ and MC₁ receptors respectively). Enhances intracavernosal pressure and stimulates erectile activity in rats ex copula following systemic administration.

Technical Data for THIQ

M. Wt	589.17 kDa
Formula	C₃₃H₄₁ClN₆O₂
Storage	Store at -20°C
Purity	≥95%
CAS Number	312637-48-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for THIQ

Solubility

Soluble Soluble to 10 mM in DMSO

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References for THIQ

References are publications that support the biological activity of the product.

Martin et al. Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula. Eur.J.Pharmacol., 2002;454:71 PMID: 12409007
Mutulis et al. New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ". J.Med.Chem., 2004;47:4613 PMID: 15317471
Sebhat et al. Design and pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-methyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective melanocorti J.Med.Chem., 2002;45:4589 PMID: 12361385