Tiagabine hydrochloride

Biological Activity for Tiagabine hydrochloride

Technical Data for Tiagabine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tiagabine hydrochloride

References for Tiagabine hydrochloride

References are publications that support the biological activity of the product.

• Dhar et al. Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA updake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3. J.Med.Chem., 1994;37:2334 PMID: 8057281
• Laughlin et al. Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabap. in mouse models of acute, prolonged, and chronic nociception. J.Pharmacol.Exp.Ther., 2002;302:1168 PMID: 12183677
• Andersen et al. The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug ca J.Med.Chem., 1993;36:1716 PMID: 8510100