TL 13-110

Name: TL 13-110
Brand: Tocris Bioscience
SKU: 6746

Tocris Bioscience, part of Bio-Techne | Catalog # 6746

COA / SDS

Negative control for TL 13-112 (Cat. No. 6745)

Key Product Details

Description:	Negative control for TL 13-112 (Cat. No. 6745)
Chemical Name:	N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	988.59

View Full Technical Details for TL 13-110

Technical Data
Citations

Biological Activity for TL 13-110

TL 13-110 is a negative control for TL 13-112 (Cat. No. 6745). Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC₅₀ = 0.34 nM).

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for TL 13-110

M. Wt	988.59
Formula	C₄₉H₆₂ClN₉O₉S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2229037-09-4
Smiles	CC(C)OC1=CC(C2CCN(CCOCCOCCNC(CNC3=CC=CC4=C3C(N(C5CCCNC5=O)C4=O)=O)=O)CC2)=C(C)C=C1NC6=NC=C(Cl)C(NC7=CC=CC=C7S(=O)(C(C)C)=O)=N6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TL 13-110

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.43	50

Preparing Stock Solutions for TL 13-110

The following data is based on the product molecular weight 988.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.02 mL	10.12 mL	20.23 mL
2.5 mM	0.40 mL	2.02 mL	4.05 mL
5 mM	0.20 mL	1.01 mL	2.02 mL
25 mM	0.04 mL	0.20 mL	0.40 mL

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Reconstitution Calculator

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References for TL 13-110

References are publications that support the biological activity of the product.

Powell Chemically induced degradation of anaplastic lymphoma kinase. J.Med.Chem. 2018 PMID: 29660984