TL 13-12

Name: TL 13-12
Brand: Tocris Bioscience
SKU: 6744

Tocris Bioscience, part of Bio-Techne | Catalog # 6744

Citations (1)

COA / SDS

Selective ALK Degrader (PROTAC®)

Key Product Details

Description:	Selective ALK Degrader (PROTAC^®)
Chemical Name:	N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	961.48

View Full Technical Details for TL 13-12

Technical Data
Citations

Biological Activity for TL 13-12

TL 13-12 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC^®) (DC₅₀ values are 10 and 180 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302), conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Exhibits higher selectivity for ALK over Aurora A kinase compared with TL 13 -112 (Cat. No. 6745). Maximum degradation is exhibited at 16 h.

Negative control TL 13-22 (Cat. No. 6747) and ALK antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF4210.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for TL 13-12

M. Wt	961.48
Formula	C₄₅H₅₃ClN₁₀O₁₀S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2229037-04-9
PubChem ID	138108740
InChi Key	WXNUIPVZMJMPNM-UHFFFAOYSA-N
Smiles	COC1=C(C=CC(N2CCN(CC2)CCOCCOCCNC(CNC3=C4C(N(C(C4=CC=C3)=O)C5CCC(NC5=O)=O)=O)=O)=C1)NC6=NC=C(C(NC7=C(S(=O)(C(C)C)=O)C=CC=C7)=N6)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TL 13-12

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	96.15	100

Preparing Stock Solutions for TL 13-12

The following data is based on the product molecular weight 961.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.04 mL	5.20 mL	10.40 mL
5 mM	0.21 mL	1.04 mL	2.08 mL
10 mM	0.10 mL	0.52 mL	1.04 mL
50 mM	0.02 mL	0.10 mL	0.21 mL

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References for TL 13-12

References are publications that support the biological activity of the product.

Powell Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 2018 PMID: 29660984