Tolvaptan

Biological Activity for Tolvaptan

Technical Data for Tolvaptan

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tolvaptan

References for Tolvaptan

References are publications that support the biological activity of the product.

• Kondo et al. 7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl-amino)benzoyl ]-2,3,4,5-tetrahydro-1H-1-benzazepine (OPC-41061): a potent, orally active nonpeptide arginine vasopressin V₂ receptor antagonist. Bioorg.Med.Chem., 1999;7:1743 PMID: 10482466
• Ghali et al. Tolvaptan. Nat.Rev.Drug Discov., 2009;8:611 PMID: 19644472
• Aihara et al. Tolvaptan delays the onset of end-stage renal disease in a polycystic kidney disease model by suppressing increases in kidney volume and renal injury. J.Pharmacol.Exp.Ther., 2014;349:258 PMID: 24570071
• Morooka et al. Chronic administration of oral vasopressin type 2 receptor antagonist tolv. exerts both myocardial and renal protective effects in rats with hypertensive heart failure. Circ.Heart.Fail., 2012;5:484 PMID: 22628529