TP 003

Tocris Bioscience, part of Bio-Techne | Catalog # 4414

COA / SDS

GABAA partial agonist; acts at benzodiazepine site

Key Product Details

Description:	GABA_A partial agonist; acts at benzodiazepine site
Chemical Name:	2',4-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1'-biphenyl]-2-carbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	407.39

View Full Technical Details for TP 003

Technical Data
Citations

Biological Activity for TP 003

TP 003 is a GABA_A receptor partial agonist that demonstrates affinity for the benzodiazepine site. Potentiates GABA_A α3 response with high efficacy. Produces anxiolytic-like effects in rodent elevated plus maze via action at GABA_A α2 subtype receptors. Also evokes GABA_A α1 mediated sedation and GABA_A α3 mediated muscle relaxation in mice.

Compound Libraries for TP 003

TP 003 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TP 003

M. Wt	407.39
Formula	C₂₃H₁₆F₃N₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	628690-75-5
PubChem ID	10001434
InChi Key	SJMMDWXJSSJHOQ-UHFFFAOYSA-N
Smiles	FC1=C(C(C)(O)C)C=CN2C1=NC=C2C3=CC=C(F)C(C4=CC=C(F)C=C4C#N)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TP 003

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.74	100
	ethanol	20.37	50

Preparing Stock Solutions for TP 003

The following data is based on the product molecular weight 407.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.27 mL	24.55 mL
5 mM	0.49 mL	2.45 mL	4.91 mL
10 mM	0.25 mL	1.23 mL	2.45 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for TP 003

References are publications that support the biological activity of the product.

Fischer Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys. Psychopharmacology (Berl.) 2011 PMID: 21190016
Neumann TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABA_A receptors. Neuropharmacology 2018 PMID: 30240781
Dias Evidence for a significant role of α3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. J.Neurosci. 2005 PMID: 16291941