TP 472

Name: TP 472
Brand: Tocris Bioscience
SKU: 6000

Tocris Bioscience, part of Bio-Techne | Catalog # 6000

Citations (25)

COA / SDS

Potent BRD9/7 inhibitor

Key Product Details

Description:	Potent BRD9/7 inhibitor
Chemical Name:	3-(6-Acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	333.38

View Full Technical Details for TP 472

Technical Data
Citations

Biological Activity for TP 472

TP 472 is a potent BRD9/7 inhibitor (K_d values are 33 and 340 nM, respectively) Exhibits >30-fold selectivity for BRD9 over other bromodomains except BRD7. Cell permeable and active in vivo.

Negative Control also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 472 probe summary on the SGC website.

Compound Libraries for TP 472

TP 472 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for TP 472

M. Wt	333.38
Formula	C₂₀H₁₉N₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2079895-62-6
PubChem ID	123773279
InChi Key	RPBMXJHQYJLPDN-UHFFFAOYSA-N
Smiles	O=C(C)C1=CC(C2=CC(C(NC3CC3)=O)=CC=C2C)=C4N=CC=CN41

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TP 472

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	16.67	50

Preparing Stock Solutions for TP 472

The following data is based on the product molecular weight 333.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.00 mL	30.00 mL	59.99 mL
2.5 mM	1.20 mL	6.00 mL	12.00 mL
5 mM	0.60 mL	3.00 mL	6.00 mL
25 mM	0.12 mL	0.60 mL	1.20 mL

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Reconstitution Calculator

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References for TP 472

References are publications that support the biological activity of the product.

Hohmann and Vakoc A rationale to target the SWI/SNF complex for cancer therapy. Trends Genet. 2014 PMID: 24932742