TPCA-1

Biological Activity for TPCA-1

Technical Data for TPCA-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TPCA-1

References for TPCA-1

References are publications that support the biological activity of the product.

• SC Koeberle, A Gollowitze, J Laoukili, O Kranenburg, O Werz, A Koeberle, AP Kipp Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-kappaB-driven inflammation through redox-active mechanisms Redox Biol, 2019;28(0):101388. 2019 PMID: 31765890
• A Rodriguez-, P Sharma, M Poussin, AC Boesteanu, NG Minutolo, SB Gitto, DK Omran, MK Robinson, GP Adams, F Simpkins, DJ Powell CAR T Cells Targeting MISIIR for the Treatment of Ovarian Cancer and Other Gynecologic Malignancies Mol. Ther., 2019;0(0):. 2019 PMID: 31870622
• J O'Connell, J Porter, B Kroeplien, T Norman, S Rapecki, R Davis, D McMillan, T Arakaki, A Burgin, D Fox Iii, T Ceska, F Lecomte, A Maloney, A Vugler, B Carrington, BP Cossins, T Bourne, A Lawson Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer Nat Commun, 2019;10(1):5795. 2019 PMID: 31857588
• Burke S, Goff M, Updegraff B, Lu D, Brown P, Minkin S, Biggerstaff J, Zhao L, Karlstad M, Collier J Regulation of the CCL2 Gene in Pancreatic beta-Cells by IL-1beta and Glucocorticoids: Role of MKP-1. PLoS ONE, 2012;7(10):e46986. 2012 PMID: 23056550
• Burke S, Lu D, Sparer T, Masi T, Goff M, Karlstad M, Collier J NF-kappaB and STAT1 control CXCL1 and CXCL2 gene transcription. Am J Physiol Endocrinol Metab, 2014;306(2):E131-49. 2014 PMID: 24280128
• LH Loo, NM Bougen-Zhu, WC Tan Early spatiotemporal-specific changes in intermediate signals are predictive of cytotoxic sensitivity to TNF? and co-treatments Sci Rep, 2017;7(0):43541. 2017 PMID: 28272488
• Haljasorg U, Bichele R, Saare M, Guha M, Maslovskaja J, Kond K, Remm A, Pihlap M, Tomson L, Kisand K, Laan M, Peterson P A highly conserved NF-kappaB-responsive enhancer is critical for thymic expression of Aire in mice. Eur J Immunol, 2015;45(12):3246-56. 2015 PMID: 26364592
• Podolin et al. Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IκB kinase 2, TPCA-1 (2-[aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and J.Pharmacol.Exp.Ther., 2005;312:373 PMID: 15316093
• Birrell et al. IK-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma. Am.J.Respir.Crit.Care Med., 2005;172:962 PMID: 16002568
• Birrell et al. IκB kinase-2-independent and-dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic. Mol.Pharmacol., 2006;69:1791 PMID: 16517756