TPPB

Name: TPPB
Brand: Tocris Bioscience
SKU: 5343

Tocris Bioscience, part of Bio-Techne | Catalog # 5343

Citations (15)

COA / SDS

High affinity PKC activator; also APP modulator

Key Product Details

Description:	High affinity PKC activator; also APP modulator
Chemical Name:	(2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienamide
Purity:	≥98% (HPLC)
Molecular Weight:	501.54

View Full Technical Details for TPPB

Technical Data
Citations

Biological Activity for TPPB

TPPB is a high affinity and cell permeable protein kinase C activator (K_i =11.9 nM), which induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPPα.

Technical Data for TPPB

M. Wt	501.54
Formula	C₂₇H₃₀F₃N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	497259-23-1
PubChem ID	9935767
InChi Key	WOLVEMPZUIFSII-IHHOKICGSA-N
Smiles	CC([C@@H]1N(C2=CC=C(C=C2C[C@H](NC1=O)CO)NC(/C=C/C=C/C3=CC=C(C(F)(F)F)C=C3)=O)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TPPB

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.08	50

Preparing Stock Solutions for TPPB

The following data is based on the product molecular weight 501.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.99 mL	19.94 mL	39.88 mL
2.5 mM	0.80 mL	3.99 mL	7.98 mL
5 mM	0.40 mL	1.99 mL	3.99 mL
25 mM	0.08 mL	0.40 mL	0.80 mL

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References for TPPB

References are publications that support the biological activity of the product.

Chen A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat.Chem.Biol. 2009 PMID: 19287398
Kozikowski New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα. J.Med.Chem. 2003 PMID: 12540236
Rezania Reversal of diabetes with Ins-producing cells derived in vitro from human pluripotent stem cells. Nat.Biotechnol. 2014 PMID: 25211370