TRAM 1

Name: TRAM 1
Brand: Tocris Bioscience
SKU: 8121

Tocris Bioscience, part of Bio-Techne | Catalog # 8121

Citations (1)

COA / SDS

Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags

Key Product Details

Description:	Chemical inducer of proximity for dTAG protein FKBP^F36V and ecDHFR tags
Chemical Name:	(R)-1-(3-(2-((3-(4-((2,4-Diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)amino)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	1009.17

View Full Technical Details for TRAM 1

Technical Data
Citations

Biological Activity for TRAM 1

TRAM 1 is a targeted relocalization activating molecule (TRAM) and chemical inducer of proximity for the dTAG protein FKBP12^F36V and ecDHFR tags. Can be used to shuttle and redistribute proteins in live cells.

Technical Data for TRAM 1

M. Wt	1009.17
Formula	C₅₄H₆₈N₆O₁₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	SGECTVFBOKCZAI-YZBUDRBASA-N
Smiles	O=C(O[C@H](CCC1=CC(OC)=C(C=C1)OC)C2=CC(OCC(NCCCOC3=C(C=C(C=C3OC)CC4=CN=C(N=C4N)N)OC)=O)=CC=C2)[C@@H]5CCCCN5C([C@@H](CC)C6=CC(OC)=C(C(OC)=C6)OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TRAM 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	100.92	100

Preparing Stock Solutions for TRAM 1

The following data is based on the product molecular weight 1009.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.99 mL	4.95 mL	9.91 mL
5 mM	0.20 mL	0.99 mL	1.98 mL
10 mM	0.10 mL	0.50 mL	0.99 mL
50 mM	0.02 mL	0.10 mL	0.20 mL

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References for TRAM 1

References are publications that support the biological activity of the product.

Ng Targeted protein relocalization via protein transport coupling. Nature 2024 PMID: 39294374