TRAM 34

Name: TRAM 34
Brand: Tocris Bioscience
SKU: 2946

Tocris Bioscience, part of Bio-Techne | Catalog # 2946

(1)

Citations (103)

COA / SDS

Potent and highly selective KCa3.1 (IK) channel blocker

Key Product Details

Chemical Name:	1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
Purity:	≥99%
Molecular Weight:	344.84 kDa

View Full Technical Details for TRAM 34

Technical Data
Citations / Reviews (1)

Biological Activity for TRAM 34

TRAM 34 is a potent and highly selective blocker of intermediate conductance Ca²⁺-activated K⁺ channels (K_Ca3.1) (K_d = 20 nM). Exhibits 200-1500-fold selectivity over K_V, BK_Ca, K_Ca2, Na⁺, CRAC and Cl^- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.

Technical Data for TRAM 34

M. Wt	344.84 kDa
Formula	C₂₂H₁₇ClN₂
Storage	Store at +4°C
Purity	≥99%
CAS Number	289905-88-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TRAM 34

Solubility

Soluble Soluble to 10 mM in DMSO with gentle warming

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References for TRAM 34

References are publications that support the biological activity of the product.

S Gaertner, C Auger, MA Farooq, B Pollet, S Khemais-Be, ZR Niazi, S Schrevens, SH Park, F Toti, D Stephan, VB Schini-Ker Oral Intake of EPA:DHA 6:1 by Middle-Aged Rats for One Week Improves Age-Related Endothelial Dysfunction in Both the Femoral Artery and Vein: Role of Cyclooxygenases Int J Mol Sci, 2020;21(3):. 2020 PMID: 32019237
Schilling and Eder TRAM-34 inhibits nonselective cation channels. Pflugers Arch., 2007;454:559 PMID: 17318643
Wang et al. An intermediate-conductance Ca²⁺-activated K⁺ channel mediates B lymphoma cell cycle progression induced by serum. Pflugers Arch., 2007;454:945 PMID: 17429684
Wulff et al. Design of a potent and selective inhibitor of the intermediate-conductance Ca²⁺-activated K⁺ channel, IKCa1: a potential immunosuppressant. Proc.Natl.Acad.Sci. USA, 2000;97:8151