Trequinsin hydrochloride

Name: Trequinsin hydrochloride
Brand: Tocris Bioscience
SKU: 2337

Tocris Bioscience, part of Bio-Techne | Catalog # 2337

Citations (4)

COA / SDS

Highly potent PDE3 inhibitor

Key Product Details

Chemical Name:	2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride
Purity:	≥97%
Molecular Weight:	441.95 kDa

View Full Technical Details for Trequinsin hydrochloride

Technical Data
Citations

Biological Activity for Trequinsin hydrochloride

Trequinsin hydrochloride is a highly potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC₅₀ = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC₅₀ = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models. Also activates CatSper channels, increases intracellular Ca²⁺ and cGMP levels, and decreases potassium channel activity in sperm.

Technical Data for Trequinsin hydrochloride

M. Wt	441.95 kDa
Formula	C₂₄H₂₇N₃O₃.HCl
Storage	Desiccate at RT
Purity	≥97%
CAS Number	78416-81-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Trequinsin hydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for Trequinsin hydrochloride

References are publications that support the biological activity of the product.

Ruppert and Weithmann HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro. Life Sci., 1982;31:2037 PMID: 6294426
Lal et al. Trequinsin, a potent new antihypertensive vasodilator in the series of 2-(arylimino)-3-alkyl-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-ones. J.Med.Chem., 1984;27:1470 PMID: 6492077
Agarwal et al. Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences. Thromb.Res., 1987;47:191 PMID: 2821650
McBrinn et al. Novel pharmacological actions of Trequinsin Hydrochloride improve human sperm cell motility and function. Br.J.Pharmacol., 2019; PMID: 31368510