TRO 19622

Name: TRO 19622
Brand: Tocris Bioscience
SKU: 2906

Tocris Bioscience, part of Bio-Techne | Catalog # 2906

Citations (20)

COA / SDS

Binds voltage-dependent anion channel (VDAC)

Key Product Details

Description:	Binds voltage-dependent anion channel (VDAC)
Alternative Names:	Olesoxime
Chemical Name:	Cholest-4-en-3-one oxime
Purity:	≥98% (HPLC)
Molecular Weight:	399.65

View Full Technical Details for TRO 19622

Technical Data
Citations

Biological Activity for TRO 19622

TRO 19622 is a neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo. Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein; thought to inhibit MPTP opening.

Technical Data for TRO 19622

M. Wt	399.65
Formula	C₂₇H₄₅NO
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	22033-87-0
PubChem ID	76971721
InChi Key	QNTASHOAVRSLMD-GYKMGIIDSA-N
Smiles	[H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]([H])4[C@@H](CCCC(C)C)C)=NO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TRO 19622

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	19.98	50
	ethanol	7.99	20

Preparing Stock Solutions for TRO 19622

The following data is based on the product molecular weight 399.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.00 mL	25.02 mL	50.04 mL
2.5 mM	1.00 mL	5.00 mL	10.01 mL
5 mM	0.50 mL	2.50 mL	5.00 mL
25 mM	0.10 mL	0.50 mL	1.00 mL

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References for TRO 19622

References are publications that support the biological activity of the product.

Bordet Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J.Pharmacol.Exp.Ther. 2007 PMID: 17496168