TRPC6-PAM-C20

Name: TRPC6-PAM-C20
Brand: Tocris Bioscience
SKU: 6875

Tocris Bioscience, part of Bio-Techne | Catalog # 6875

Citations (2)

COA / SDS

Selective positive allosteric modulator (PAM) of TRPC6

Key Product Details

Description:	Selective positive allosteric modulator (PAM) of TRPC6
Chemical Name:	3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	363.41

View Full Technical Details for TRPC6-PAM-C20

Technical Data
Citations

Biological Activity for TRPC6-PAM-C20

TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. Selectively activates TRPC6 over other TRP channels. Also activates TRPA1. Induces transient increase in intracellular Ca²⁺ in HEK cells expressing TRPC6 (EC₅₀ = 2.37 μM). Potentiates OAG (1-oleoyl-1-acetyl-sn-glycerol)-induced Ca²⁺ influx in human platelets, and enhances OAG-induced platelet aggregation.

Technical Data for TRPC6-PAM-C20

M. Wt	363.41
Formula	C₂₂H₂₁NO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	667427-75-0
PubChem ID	1081484
InChi Key	SNICUMZYPOCXCO-UHFFFAOYSA-N
Smiles	COC1=C(OC)C=C2C(CC(C)(C)N=C2C2=CC3=CC=CC=C3OC2=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TRPC6-PAM-C20

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.34	100
	ethanol	7.27	20

Preparing Stock Solutions for TRPC6-PAM-C20

The following data is based on the product molecular weight 363.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.75 mL	13.76 mL	27.52 mL
5 mM	0.55 mL	2.75 mL	5.50 mL
10 mM	0.28 mL	1.38 mL	2.75 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for TRPC6-PAM-C20

References are publications that support the biological activity of the product.

Häfner Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels. Cell Calcium 2019 PMID: 30594060