TTNPB

Name: TTNPB
Brand: Tocris Bioscience
SKU: 0761

Tocris Bioscience, part of Bio-Techne | Catalog # 0761

Citations (49)

COA / SDS

Retinoic acid analog; RAR agonist

Key Product Details

Chemical Name:	4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
Purity:	≥98%
Molecular Weight:	348.48 kDa

View Full Technical Details for TTNPB

Technical Data
Citations

Biological Activity for TTNPB

TTNPB is an extremely potent analog of retinoic acid, selective for the retinoic acid receptor (RAR) subtype. Enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).

Technical Data for TTNPB

M. Wt	348.48 kDa
Formula	C₂₄H₂₈O₂
Storage	Desiccate at -20°C
Purity	≥98%
CAS Number	71441-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TTNPB

Solubility

Soluble Soluble to 10 mM in DMSO

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References for TTNPB

References are publications that support the biological activity of the product.

Whelan J, Wang L, Chen J, Metts M, Nasser T, McGoldrick L, Bridges L Retinoids induce integrin-independent lymphocyte adhesion through RAR-alpha nuclear receptor activity. Biochem Biophys Res Commun, 2014;454(4):537-542. 2014 PMID: 25450689
Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Minucci et al. Retinoid X receptor-selective ligands produce malformations in Xenopus embryos. Proc.Natl.Acad.Sci.U.S.A., 1996;93:1803 PMID: 8700839
Loeliger et al. Arotinoids, a new class of highly active retinoids. Eur.J.Med.Chem.-Chim.Ther., 1980;15:9
Hou et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science, 2013;341:651 PMID: 23868920