Tubacin

Name: Tubacin
Brand: Tocris Bioscience
SKU: 3402

Tocris Bioscience, part of Bio-Techne | Catalog # 3402

Citations (10)

COA / SDS

HDAC6 inhibitor; inhibits α-tubulin deacetylation

Key Product Details

Chemical Name:	N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Purity:	≥96%
Molecular Weight:	721.86 kDa

View Full Technical Details for Tubacin

Technical Data
Citations

Biological Activity for Tubacin

Tubacin is a selective inhibitor of HDAC6; inhibits the second deacetylase domain (DD2). Does not inhibit HDAC6 histone deacetylase activity; reversibly inhibits α-tubulin deacetylation. Increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.

Technical Data for Tubacin

M. Wt	721.86 kDa
Formula	C₄₁H₄₃N₃O₇S
Storage	Store at -20°C
Purity	≥96%
CAS Number	1350555-93-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tubacin

Solubility

Soluble Soluble to 10 mM in DMSO

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References for Tubacin

References are publications that support the biological activity of the product.

Haggarty et al. Multidimensional chemical genetic analysis of diversity-orientated synthesis-derived deacetylase inhibitors using cell-based assays. Chem.Biol., 2003;10:383 PMID: 12770821
Jiang et al. Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome. J.Neurosci., 2008;28:12993 PMID: 19036992
Haggarty et al. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc.Natl.Acad.Sci.USA, 2003;100:4389 PMID: 12677000