U 73343

Name: U 73343
Brand: Tocris Bioscience
SKU: 4133

Tocris Bioscience, part of Bio-Techne | Catalog # 4133

Citations (66)

COA / SDS

Analog of U 73122 (Cat. No. 1268)

Key Product Details

Description:	Analog of U 73122 (Cat. No. 1268)
Chemical Name:	1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione
Purity:	≥98% (HPLC)
Molecular Weight:	466.66

View Full Technical Details for U 73343

Technical Data
Citations

Biological Activity for U 73343

U 73343 is an analog of U 73122; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTPγS-induced Ca²⁺ influx in hepatocytes.

Active Analog also available.

Technical Data for U 73343

M. Wt	466.66
Formula	C₂₉H₄₂N₂O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	142878-12-4
PubChem ID	114825
InChi Key	CJHWFIUASFBCKN-ZRJUGLEFSA-N
Smiles	[H][C@]23[C@@]([C@]([H])(CC[C@@H]4NCCCCCCN5C(CCC5=O)=O)[C@]4(C)CC3)([H])CCC1=CC(OC)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for U 73343

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	4.67	10 with gentle warming
	ethanol	2.33	5 with gentle warming

Preparing Stock Solutions for U 73343

The following data is based on the product molecular weight 466.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.43 mL	107.14 mL	214.29 mL
0.5 mM	4.29 mL	21.43 mL	42.86 mL
1 mM	2.14 mL	10.71 mL	21.43 mL
5 mM	0.43 mL	2.14 mL	4.29 mL

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References for U 73343

References are publications that support the biological activity of the product.

Berven and Barritt Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca²⁺ inflow. Biochem.Pharmacol. 1995 PMID: 7763279
Kataoka Activation of P2X₇ receptors induces CCL3 production in microglial cells through transcription factor NFAT. J.Neurochem. 2009 PMID: 19014371
Ma Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J.Pharmacol.Exp.Ther. 2009 PMID: 19023039
Muto The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J.Pharmacol.Exp.Ther. 1997 PMID: 9316850