UC 112

Name: UC 112
Brand: Tocris Bioscience
SKU: 5251

Tocris Bioscience, part of Bio-Techne | Catalog # 5251

Citations (1)

COA / SDS

IAP and XIAP inhibitor; antitumor

Discontinued Product

5251 has been discontinued. View all Apoptosis Inducer Compounds products.

Key Product Details

Description:	IAP and XIAP inhibitor; antitumor
Chemical Name:	5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol
Purity:	≥98% (HPLC)
Molecular Weight:	348.44

View Full Technical Details for UC 112

Technical Data
Citations

Biological Activity for UC 112

UC 112 is an iAP inhibitor (IC₅₀ values from 0.7 - 3.4 μM); inhibits cell growth in multiple cancer cell lines and in a melanoma xenograft model in vivo. Also suppresses X-linked inhibitor of apoptosis protein (XIAP) and survivin levels. Inhibits the growth of P-glycoproteins and activates caspase-3/7 and caspase-9.

Technical Data for UC 112

M. Wt	348.44
Formula	C₂₂H₂₄N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	383392-66-3
PubChem ID	3426979
InChi Key	LTGLGIQQZXSLLF-UHFFFAOYSA-N
Smiles	OC1=C3C(C=CC=N3)=C(COCC4=CC=CC=C4)C=C1CN2CCCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for UC 112

References are publications that support the biological activity of the product.

Wang Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J.Pharmacol.Exp.Ther. PMID: 24623800

UC 112

Tocris Bioscience, part of Bio-Techne | Catalog # 5251

Key Product Details

Biological Activity for UC 112

Technical Data for UC 112

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for UC 112

Product Documents for UC 112

COA

Certificate of Analysis

SDS

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