Apoptosis Inducer Compounds Products
Apoptosis inducers produce pro-apoptotic effects via different mechanisms. These include DNA cross-linking, inhibition of antiapoptotic proteins, and activation of caspases. These apoptosis inducers can target specific cellular processes to induce antitumor or antineoplastic effects.
31 results for "Apoptosis Inducer Compounds" in Products
31 results for "Apoptosis Inducer Compounds" in Products
Apoptosis Inducer Compounds Products
Apoptosis inducers produce pro-apoptotic effects via different mechanisms. These include DNA cross-linking, inhibition of antiapoptotic proteins, and activation of caspases. These apoptosis inducers can target specific cellular processes to induce antitumor or antineoplastic effects.
Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
| Chemical Name: | 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione |
| Purity: | ≥99% (HPLC) |
Potent pro-apoptotic anticancer agent; activates caspase-3
| Alternate Names: | CDDP |
| Chemical Name: | cis-Diaminodichloroplatinum |
Pan-histone deacetylase inhibitor
| Chemical Name: | (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide |
| Purity: | ≥98% (HPLC) |
Antitumor antibiotic agent. Inhibits DNA topoisomerase II
| Alternate Names: | Adriamycin,NSC 123127 |
| Chemical Name: | 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride |
| Purity: | ≥98% (HPLC) |
DNA cross-linking antitumor agent
| Alternate Names: | Ametycine |
| Chemical Name: | [1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione |
| Purity: | ≥98% (HPLC) |
DNA-methylating antitumor agent
| Alternate Names: | NSC 362856,CCRG 81045 |
| Chemical Name: | 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide |
| Purity: | ≥99% (HPLC) |
DNA cross-linking antitumor agent
| Alternate Names: | Eloxatin |
| Chemical Name: | Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II) |
| Purity: | ≥99% (HPLC) |
Inhibits RNA polymerase
| Chemical Name: | 2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7,10,13] oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide |
| Purity: | ≥95% (HPLC) |
Selectively induces cancer cell apoptosis
| Chemical Name: | 2-[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol hydrochloride |
| Purity: | ≥99% (HPLC) |
Downregulates Bcl-2 and Mcl-1; pro-apoptotic
| Chemical Name: | (-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde |
| Purity: | ≥98% (HPLC) |
Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
| Chemical Name: | (+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid |
DNA alkylator; antitumor and induces diabetes
| Alternate Names: | Streptozotocin |
| Chemical Name: | 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose |
| Purity: | ≥95% (HPLC) |
Alkylating agent; chemotherapeutic
| Chemical Name: | 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide |
| Purity: | ≥99% (HPLC) |
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
| Chemical Name: | 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide |
| Purity: | ≥98% (HPLC) |
DNA cross-linking antitumor agent
| Alternate Names: | NSC 241240,Paraplatin,JM 8 |
| Chemical Name: | cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II) |
| Purity: | ≥99% (HPLC) |
Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
| Alternate Names: | Kempferol |
| Chemical Name: | 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% (HPLC) |
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
| Chemical Name: | 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide |
| Purity: | ≥98% (HPLC) |
Purine analog; inhibits DNA synthesis
| Chemical Name: | 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine |
| Purity: | ≥98% (HPLC) |
Thymidine analog for labeling DNA; can be linked to a fluorophore by click chemistry
| Chemical Name: | 5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| Purity: | ≥95% (HPLC) |
Hypoxia-activated DNA alkylating agent prodrug
| Chemical Name: | (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)phosphorodiamidate |
| Applications: | AdAct |
| Purity: | ≥98% (HPLC) |
Potent fatty acid synthase inhibitor; proapoptotic
| Alternate Names: | trans-C 75 |
| Chemical Name: | (2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid |
| Purity: | ≥95% (HPLC) |
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
| Chemical Name: | (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one |
| Purity: | ≥98% (HPLC) |
Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression
| Chemical Name: | (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one |
| Purity: | ≥98% (HPLC) |
Deoxyadenosine analog; pro-apoptotic
| Alternate Names: | 2-Chloro-2'-deoxyadenosine |
| Chemical Name: | (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol |
| Purity: | ≥99% (HPLC) |
High affinity and selective activator of Bax
| Chemical Name: | 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol |
| Purity: | ≥98% (HPLC) |
