UNC 0638

Name: UNC 0638
Brand: Tocris Bioscience
SKU: 4343

Tocris Bioscience, part of Bio-Techne | Catalog # 4343

Citations (15)

COA / SDS

Selective G9a and GLP inhibitor

Key Product Details

Description:	Selective G9a and GLP inhibitor
Chemical Name:	2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
Purity:	≥98% (HPLC)
Molecular Weight:	509.73

View Full Technical Details for UNC 0638

Technical Data
Citations

Biological Activity for UNC 0638

UNC 0638 is a selective inhibitor of G9a and GLP histone lysine methyltransferases (IC₅₀ values are < 15 nM and 19 nM for G9a and GLP respectively, and > 10000 nM for a range of other histone methyltransferases). Potently inhibits dimethylation of H3K9 in MCF-7 cells (IC₅₀ = 70 nM). Restores metabolic and antiviral function in exhausted CD8⁺ T cells from patients with chronic HCV infection. Cell permeable.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 0638 probe summary on the SGC website.

Compound Libraries for UNC 0638

UNC 0638 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 0638 is reviewed on the chemical probes website.

Technical Data for UNC 0638

M. Wt	509.73
Formula	C₃₀H₄₇N₅O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1255580-76-7
PubChem ID	46224516
InChi Key	QOECJCJVIMVJGX-UHFFFAOYSA-N
Smiles	CC(C)N(CC5)CCC5NC1=C2C(C=C(OCCCN4CCCC4)C(OC)=C2)=NC(C3CCCCC3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UNC 0638

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	50.97	100
	ethanol	50.97	100

Preparing Stock Solutions for UNC 0638

The following data is based on the product molecular weight 509.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.96 mL	9.81 mL	19.62 mL
5 mM	0.39 mL	1.96 mL	3.92 mL
10 mM	0.20 mL	0.98 mL	1.96 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

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References for UNC 0638

References are publications that support the biological activity of the product.

Liu Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J.Med.Chem. 2011 PMID: 21780790
Barili Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection. Nat.Commun. 2020 PMID: 32001678
Vedadi A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat.Chem.Biol. 2011 PMID: 21743462