Upadacitinib

Name: Upadacitinib
Brand: Tocris Bioscience
SKU: 7783

Tocris Bioscience, part of Bio-Techne | Catalog # 7783

COA / SDS

JAK1-selective inhibitor

Key Product Details

Description:	JAK1-selective inhibitor
Chemical Name:	(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	380.37

View Full Technical Details for Upadacitinib

Technical Data
Citations

Biological Activity for Upadacitinib

Upadacitinib is a potent and selective JAK1 inhibitor (IC₅₀ = 47 nM). In a cellular assay, Upadacitinib shows selectivity for JAK1 over JAK2, JAK3 and TYK2 (IC₅₀ values are 0.014 μM, 0.593 μM, 1860 μM and 2715 μM). In vivo, Upadacitinib suppresses paw swelling and bone destruction in a rat model of arthritis.

Technical Data for Upadacitinib

M. Wt	380.37
Formula	C₁₇H₁₉F₃N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1310726-60-3
PubChem ID	58557659
InChi Key	WYQFJHHDOKWSHR-MNOVXSKESA-N
Smiles	C(C)[C@H]1[C@@](C=2N3C4=C(N=CC3=NC2)NC=C4)(CN(C(NCC(F)(F)F)=O)C1)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Upadacitinib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.04	100
	ethanol	19.02	50

Preparing Stock Solutions for Upadacitinib

The following data is based on the product molecular weight 380.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.63 mL	13.15 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
10 mM	0.26 mL	1.31 mL	2.63 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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Reconstitution Calculator

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References for Upadacitinib

References are publications that support the biological activity of the product.

Parmentier In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494). BMC Rheumatol. 2018 PMID: 30886973