Valinomycin

Name: Valinomycin
Brand: Tocris Bioscience
SKU: 3373

Tocris Bioscience, part of Bio-Techne | Catalog # 3373

(2)

Citations (16)

COA / SDS

Selective K+ ionophore

Key Product Details

Chemical Name:	Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
Purity:	≥90%
Molecular Weight:	1111.32 kDa

View Full Technical Details for Valinomycin

Technical Data
Citations / Reviews (2)

Biological Activity for Valinomycin

Valinomycin is a selective K⁺ ionophore (K_0.5 values are 48, 73, 75, 93 and 246 mM for K⁺, Rb⁺, Cs⁺, Na⁺ and Li⁺ respectively) that transports K⁺ across biological and artificial lipid membranes. Inhibits Ca²⁺-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro.

Technical Data for Valinomycin

M. Wt	1111.32 kDa
Formula	C₅₄H₉₀N₆O₁₈
Storage	Store at -20°C
Purity	≥90%
CAS Number	2001-95-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Valinomycin

Solubility

Soluble Soluble to 25 mM in DMSO and to 25 mM in ethanol

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References for Valinomycin

References are publications that support the biological activity of the product.

E Fessler, EM Eckl, S Schmitt, IA Mancilla, MF Meyer-Bend, M Hanf, J Philippou-, S Krebs, H Zischka, LT Jae A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol Nature, 2020;579(7799):433-437. 2020 PMID: 32132706
Davidson and Berman Interaction of valinomycin and monovalent cations with the (Ca²⁺,Mg²⁺)-ATPase of skeletal muscle sarcoplasmic reticulum. J.Biol.Chem., 1985;260:7325 PMID: 3158656
Abdalah et al. Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci.Letts., 2006;405:68
Rose and Jenkins The effects of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes. Bioelectrochem., 2007;70:387