Valproic acid, sodium salt

Biological Activity for Valproic acid, sodium salt

Technical Data for Valproic acid, sodium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Valproic acid, sodium salt

References for Valproic acid, sodium salt

References are publications that support the biological activity of the product.

• Lee, Rimi, Kim, Il-Sun, Han, Nalae, Yun, Seokhwan, Park, Kook In, Yoo, Kyung-Hw Real-time discrimination between proliferation and neuronal and astroglial differentiation of human neural stem cells. Sci Rep, 2014;4(0):6319. 2014 PMID: 25204726
• N Zeltner, F Fattahi, NC Dubois, N Saurat, F Lafaille, L Shang, B Zimmer, J Tchieu, MA Soliman, G Lee, JL Casanova, L Studer Capturing the biology of disease severity in a PSC-based model of familial dysautonomia Nat. Med., 2016;22(12):1421-1427. 2016 PMID: 27841875
• Kim et al. Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J.Pharmacol.Exp.Ther., 2007;321:892 PMID: 17371805
• Qing et al. Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models. J.Exp.Med., 2008;205:2781 PMID: 18955571
• Phiel et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J.Biol.Chem., 2001;276:36734 PMID: 11473107
• Kostrouchova et al. Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biologica, 2007;53:37 PMID: 17448293
• Huangfu et al. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat.Biotechnol., 2008;26:1269 PMID: 18849973
• Gordon et al. A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature, 2020; PMID: 32353859