Valproic acid, sodium salt

Name: Valproic acid, sodium salt
Brand: Tocris Bioscience
SKU: 2815
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2815

(2)

Citations (15)

COA / SDS

Histone deacetylase inhibitor

Key Product Details

Description:	Histone deacetylase inhibitor
Alternative Names:	VPA,Sodium Valproate
Chemical Name:	Sodium 2-propylpentanoate
Molecular Weight:	166.19

View Full Technical Details for Valproic acid, sodium salt

Technical Data
Citations / Reviews (2)

Biological Activity for Valproic acid, sodium salt

Valproic acid, sodium salt is a histone deacetylase inhibitor (IC₅₀ = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na⁺ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2.

For more information about how Valproic acid, sodium salt may be used, see our protocol:

Highly Efficient Generation of CiPSCs from MEFs

Compound Libraries for Valproic acid, sodium salt

Valproic acid, sodium salt is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Valproic acid, sodium salt

M. Wt	166.19
Formula	C₈H₁₅NaO₂
Storage	Desiccate at RT
CAS Number	1069-66-5
PubChem ID	16760703
InChi Key	AEQFSUDEHCCHBT-UHFFFAOYSA-M
Smiles	[Na+].CCCC(CCC)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Valproic acid, sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	16.62	100
	DMSO	8.31	50

Preparing Stock Solutions for Valproic acid, sodium salt

The following data is based on the product molecular weight 166.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.02 mL	30.09 mL	60.17 mL
5 mM	1.20 mL	6.02 mL	12.03 mL
10 mM	0.60 mL	3.01 mL	6.02 mL
50 mM	0.12 mL	0.60 mL	1.20 mL

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References for Valproic acid, sodium salt

References are publications that support the biological activity of the product.

Gordon A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 2020 PMID: 32353859
Huangfu Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat.Biotechnol. 2008 PMID: 18849973
Qing Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models. J.Exp.Med. 2008 PMID: 18955571
Kim Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J.Pharmacol.Exp.Ther. 2007 PMID: 17371805
Kostrouchova Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biologica 2007 PMID: 17448293
Phiel Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J.Biol.Chem. 2001 PMID: 11473107

Product Documents for Valproic acid, sodium salt

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Valproate (Valproic acid), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov