VH 032 amide-PEG4-amine

Name: VH 032 amide-PEG4-amine
Brand: Tocris Bioscience
SKU: 6464
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6464

COA / SDS

VHL ligand with PEG linker and terminal amine for onward chemistry

Key Product Details

Description:	VHL ligand with PEG linker and terminal amine for onward chemistry
Alternative Names:	(S,R,S)-AHPC-PEG4-NH₂
Chemical Name:	(2S,4R)-1-((S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	736.75

View Full Technical Details for VH 032 amide-PEG4-amine

Technical Data
Citations

Biological Activity for VH 032 amide-PEG4-amine

VH 032 amide-PEG4-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC^® research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was VH 032 - linker 2

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for VH 032 amide-PEG4-amine

M. Wt	736.75
Formula	C₃₂H₄₉N₅O₈S.2HCl
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2446474-04-8
PubChem ID	131704498
InChi Key	YEPRWQRHNYBGLC-HGIJPQKFSA-N
Smiles	O=C(N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)=O)COCCOCCOCCOCCN.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VH 032 amide-PEG4-amine

References are publications that support the biological activity of the product.

Zengerle Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem.Biol. 2015 PMID: 26035625
Chan Impact of target warhead and linkage vector on inducing protein degradation: comparison of bromodomain and extra-terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds. J.Med.Chem. 2018 PMID: 28595007
Salami Waste disposal-An attractive strategy for cancer therapy. Science 2017 PMID: 28302825