VH 032, propargyl

Name: VH 032, propargyl
Brand: Tocris Bioscience
SKU: 6683

Tocris Bioscience, part of Bio-Techne | Catalog # 6683

COA / SDS

Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs

Key Product Details

Description:	Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs
Chemical Name:	(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(prop-2-yn-1-yloxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	526.65

View Full Technical Details for VH 032, propargyl

Technical Data
Citations

Biological Activity for VH 032, propargyl

VH 032, propargyl is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC^® research and development; incorporates an E3 ligase ligand with terminal propargyl ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for VH 032, propargyl

M. Wt	526.65
Formula	C₂₇H₃₄N₄O₅S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2098799-78-9
Smiles	CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCC#C)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VH 032, propargyl

References are publications that support the biological activity of the product.

Wurz A "click chemistry platform" for the rapid synthesis of bispecific molecules for inducing protein degradation. J.Med.Chem. 2018 PMID: 28378579