VO-OHpic

Name: VO-OHpic
Brand: Tocris Bioscience
SKU: 3591

Tocris Bioscience, part of Bio-Techne | Catalog # 3591

Citations (10)

COA / SDS

Potent PTEN inhibitor

Key Product Details

Chemical Name:	(OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato-κ-N¹,κO²)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO²]oxovanadate(1-),hydrogen
Purity:	≥98%

View Full Technical Details for VO-OHpic

Technical Data
Citations

Biological Activity for VO-OHpic

VO-OHpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) (IC₅₀ = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC₅₀ values are 588 nM, 4.03, 57.5 and >10 μM respectively). Increases PIP₂ and PIP₃ levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated T_regs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.

Technical Data for VO-OHpic

Formula	C₁₂H₁₀N₂O₈V
Storage	Store at -20°C
Purity	≥98%
CAS Number	675848-25-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VO-OHpic

Solubility

Soluble Soluble to 100 mM in DMSO

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References for VO-OHpic

References are publications that support the biological activity of the product.

N Tellios, JC Belrose, AC Tokarewicz, C Hutnik, H Liu, A Leask, M Motolko, M Iijima, SK Parapuram TGF-? induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma Sci Rep, 2017;7(1):812. 2017 PMID: 28400560
Sharma et al. The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci.Adv., 2015;1:e1500845 PMID: 26601142
Rosivatz et al. A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem.Biol., 2006;1:780 PMID: 17240976

VO-OHpic

Tocris Bioscience, part of Bio-Techne | Catalog # 3591

Key Product Details

Biological Activity for VO-OHpic

Technical Data for VO-OHpic

Solubility for VO-OHpic

Dilution Calculator

Reconstitution Calculator

References for VO-OHpic

Product Documents for VO-OHpic

COA

Certificate of Analysis

SDS

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