VO-OHpic

Name: VO-OHpic
Brand: Tocris Bioscience
SKU: 3591

Tocris Bioscience, part of Bio-Techne | Catalog # 3591

Citations (10)

COA / SDS

Potent PTEN inhibitor

Key Product Details

Description:	Potent PTEN inhibitor
Chemical Name:	(OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato-κ-N¹,κO²)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO²]oxovanadate(1-),hydrogen
Purity:	≥98% (HPLC)
Molecular Weight:	361.16

View Full Technical Details for VO-OHpic

Technical Data
Citations

Biological Activity for VO-OHpic

VO-OHpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) (IC₅₀ = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC₅₀ values are 588 nM, 4.03, 57.5 and >10 μM respectively). Increases PIP₂ and PIP₃ levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated T_regs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.

Technical Data for VO-OHpic

M. Wt	361.16
Formula	C₁₂H₁₀N₂O₈V
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	675848-25-6
PubChem ID	90488861
InChi Key	WUAQQAGTKWKWKQ-UHFFFAOYSA-K
Smiles	OC1=C2C([O-][V+2]3(O)([O-]C(C4=NC=CC=C4[O-]3)=O)([N]2=CC=C1)=O)=O.[H+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VO-OHpic

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.12	100

Preparing Stock Solutions for VO-OHpic

The following data is based on the product molecular weight 361.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.84 mL	27.69 mL
5 mM	0.55 mL	2.77 mL	5.54 mL
10 mM	0.28 mL	1.38 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for VO-OHpic

References are publications that support the biological activity of the product.

Sharma The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci.Adv. 2015 PMID: 26601142
Rosivatz A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem.Biol. 2006 PMID: 17240976