Voriconazole

Name: Voriconazole
Brand: Tocris Bioscience
SKU: 3760

Tocris Bioscience, part of Bio-Techne | Catalog # 3760

Citations (3)

COA / SDS

Triazole antifungal agent

Key Product Details

Description:	Triazole antifungal agent
Alternative Names:	UK 109496
Chemical Name:	(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-((1H)-1,2,4-triazol-1-yl)-butan-2-ol
Purity:	≥99% (HPLC)
Molecular Weight:	349.31

View Full Technical Details for Voriconazole

Technical Data
Citations

Biological Activity for Voriconazole

Voriconazole is a triazole antifungal agent. Displays potent activity against Candida, Cryptococcus and Aspergillus species.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Voriconazole

M. Wt	349.31
Formula	C₁₆H₁₄F₃N₅O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	137234-62-9
PubChem ID	71616
InChi Key	BCEHBSKCWLPMDN-MGPLVRAMSA-N
Smiles	O[C@]([C@@H](C)C2=NC=NC=C2F)(C3=C(F)C=C(F)C=C3)CN1C=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Voriconazole

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.93	100
	ethanol	34.93	100

Preparing Stock Solutions for Voriconazole

The following data is based on the product molecular weight 349.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.86 mL	14.31 mL	28.63 mL
5 mM	0.57 mL	2.86 mL	5.73 mL
10 mM	0.29 mL	1.43 mL	2.86 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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Reconstitution Calculator

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References for Voriconazole

References are publications that support the biological activity of the product.

Kappe Antifungal activity of the new azole UK-109,496 (voriconazole). Mycoses
Marco In vitro activities of voricon. (UK-190-496) and four other antifungal agents against 394 clinical isolates of Candida spp. Antimicrob.Agents Chemother. 1998 PMID: 9449278