VU 0071063

Name: VU 0071063
Brand: Tocris Bioscience
SKU: 7057

Tocris Bioscience, part of Bio-Techne | Catalog # 7057

COA / SDS

Selective activator of SUR1 Kir6.2 channels

Key Product Details

Description:	Selective activator of SUR1 Kir6.2 channels
Chemical Name:	7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Purity:	≥98% (HPLC)
Molecular Weight:	326.4

View Full Technical Details for VU 0071063

Technical Data
Citations

Biological Activity for VU 0071063

VU 0071063 is a selective activator of SUR1 K_ir6.2 channels and pancreatic β-cell K_ATP channels (EC₅₀ = 7 μM and 0.3-10.3 μM, respectively). VU 0071063 inhibits insulin secretion in pancreatic β-cells by inducing hyperpolarization of β-cell membranes and reduces voltage-dependent calcium channel activation and Ca²⁺ influx. VU 0071063 is active in vivo and brain penetrant.

Technical Data for VU 0071063

M. Wt	326.4
Formula	C₁₈H₂₂N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	333415-38-6
PubChem ID	590142
InChi Key	ZFZAIHKQJBMYLO-UHFFFAOYSA-N
Smiles	CC(C)(C1=CC=C(CN2C=NC3=C2C(N(C)C(N3C)=O)=O)C=C1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 0071063

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	1.63	5

Preparing Stock Solutions for VU 0071063

The following data is based on the product molecular weight 326.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	61.27 mL	306.37 mL	612.75 mL
0.25 mM	12.25 mL	61.27 mL	122.55 mL
0.5 mM	6.13 mL	30.64 mL	61.27 mL
2.5 mM	1.23 mL	6.13 mL	12.25 mL

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References for VU 0071063

References are publications that support the biological activity of the product.

Kharade Structure-activity relationships, pharmacokinetics, and pharmacodynamics of the Kir6.2/SUR1-specific channel opener VU0071063. J.Pharmacol.Exp.Ther. 2019 PMID: 31201216
Raphemot Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol.Pharmacol. 2014 PMID: 24646456