VU 0650991

Name: VU 0650991
Brand: Tocris Bioscience
SKU: 6355

Tocris Bioscience, part of Bio-Techne | Catalog # 6355

Citations (1)

COA / SDS

Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant

Key Product Details

Chemical Name:	7-(4-Chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
Purity:	≥98%

View Full Technical Details for VU 0650991

Technical Data
Citations

Biological Activity for VU 0650991

VU 0650991 is a noncompetitive glucagon-like peptide-1 (GLP-1) receptor antagonist (IC₅₀ = 0.65 - 0.69 μM). Displays >40-fold selectivity for GLP-1 receptor over glucagon receptors. Blocks activity of Exendin-4 (Cat. No. 1933) in potentiating insulin secretion from primary mouse pancreatic islets in vitro. Decreases blood insulin and increases blood glucose levels in vivo. Brain penetrant and orally bioavailable.

Technical Data for VU 0650991

Formula	C₁₆H₁₁ClF₆N₄O₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	488097-06-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 0650991

Solubility

Soluble Soluble to 100 mM in DMSO

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References for VU 0650991

References are publications that support the biological activity of the product.

Nance et al. Discovery of a novel series of orally bioavailable and CNS penetrant GLP-1R noncompetitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core. J.Med.Chem., 2017;60:1611 PMID: 28103022

VU 0650991

Tocris Bioscience, part of Bio-Techne | Catalog # 6355

Key Product Details

Biological Activity for VU 0650991

Technical Data for VU 0650991

Solubility for VU 0650991

Dilution Calculator

Reconstitution Calculator

References for VU 0650991

Product Documents for VU 0650991

COA

Certificate of Analysis

SDS

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