W146

Tocris Bioscience, part of Bio-Techne | Catalog # 3602

COA / SDS

Potent and selective S1P1 receptor antagonist

Key Product Details

Description:	Potent and selective S1P₁ receptor antagonist
Alternative Names:	ML 056
Chemical Name:	[(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid
Purity:	≥98% (HPLC)
Molecular Weight:	342.37

View Full Technical Details for W146

Technical Data
Citations

Biological Activity for W146

W146 is a potent sphingosine-1-phosphate receptor S1P₁ selective antagonist (K_i = 18 nM); displays no effect at S1P₂, S1P₃ or S1P₅. Enhances capillary leakage and restores lymphocyte egress in vivo.

Technical Data for W146

M. Wt	342.37
Formula	C₁₆H₂₇N₂O₄P
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	909725-61-7
PubChem ID	6857802
InChi Key	FWJRVGZWNDOOFH-OAHLLOKOSA-N
Smiles	CCCCCCC1=CC=CC(NC([C@H](N)CCP(O)(O)=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for W146

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	3eq. NaOH	6.85	20

Preparing Stock Solutions for W146

The following data is based on the product molecular weight 342.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.60 mL	73.02 mL	146.04 mL
1 mM	2.92 mL	14.60 mL	29.21 mL
2 mM	1.46 mL	7.30 mL	14.60 mL
10 mM	0.29 mL	1.46 mL	2.92 mL

Molarity Calculator

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Reconstitution Calculator

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References for W146

References are publications that support the biological activity of the product.

Gonzalez-Cabrera Full pharmacological efficacy of a novel S1P₁ agonist that does not require S1P-like headgroup interactions. Mol.Pharmacol. 2008 PMID: 18708635
Sanna Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P₁ antagonist in vivo. Nat.Chem.Biol. 2006 PMID: 16829954