Wiskostatin

Name: Wiskostatin
Brand: Tocris Bioscience
SKU: 4434

Tocris Bioscience, part of Bio-Techne | Catalog # 4434

Citations (11)

COA / SDS

N-WASP inhibitor; inhibits Arp2/3 activation

Key Product Details

Chemical Name:	3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol
Purity:	≥99%

View Full Technical Details for Wiskostatin

Technical Data
Citations

Biological Activity for Wiskostatin

Wiskostatin is an inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP₂-induced actin polymerization (EC₅₀ ~ 4μM).

Technical Data for Wiskostatin

Formula	C₁₇H₁₈Br₂N₂O
Storage	Store at +4°C
Purity	≥99%
CAS Number	253449-04-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Wiskostatin

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Wiskostatin

References are publications that support the biological activity of the product.

Wegner et al. N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. J.Biol.Chem., 2008;283:15912 PMID: 18430734
Peterson et al. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat.Struct.Mol.Biol., 2004;11:747 PMID: 15235593
Guerriero and Weisz et al. N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am.J.Physiol.Cell Physiol., 2006;292:C1562 PMID: 17092993

Wiskostatin

Tocris Bioscience, part of Bio-Techne | Catalog # 4434

Key Product Details

Biological Activity for Wiskostatin

Technical Data for Wiskostatin

Solubility for Wiskostatin

Dilution Calculator

Reconstitution Calculator

References for Wiskostatin

Product Documents for Wiskostatin

COA

Certificate of Analysis

SDS

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