Xamoterol hemifumarate

Name: Xamoterol hemifumarate
Brand: Tocris Bioscience
SKU: 0950

Tocris Bioscience, part of Bio-Techne | Catalog # 0950

Citations (21)

COA / SDS

Selective β1 partial agonist

Key Product Details

Description:	Selective β₁ partial agonist
Alternative Names:	ICI 118,587
Chemical Name:	1-(4-Hydroxyphenoxy)-3-[2-(4-morpholinocarboxamido)ethylamino]-2-propanol hemifumarate
Purity:	≥97% (HPLC)
Molecular Weight:	397.43

View Full Technical Details for Xamoterol hemifumarate

Technical Data
Citations

Biological Activity for Xamoterol hemifumarate

Xamoterol hemifumarate is a β₁-adrenoceptor-selective partial agonist (pA₂ values are 7.4 - 7.8 and 5.2 - 6.2 at β₁- and β₂-adrenoceptors respectively).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for Xamoterol hemifumarate

Xamoterol hemifumarate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Xamoterol hemifumarate

M. Wt	397.43
Formula	C₁₆H₂₅N₃O₅.0.5C₄H₄O₄
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	73210-73-8
PubChem ID	6440459
InChi Key	QEDVGROSOZBGOZ-WXXKFALUSA-N
Smiles	[H]OC(=O)\C=C\C(=O)O[H].OC(CNCCNC(=O)N1CCOCC1)COC1=CC=C(O)C=C1.OC(CNCCNC(=O)N1CCOCC1)COC1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Xamoterol hemifumarate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water		50
	DMSO	39.74	100

Preparing Stock Solutions for Xamoterol hemifumarate

The following data is based on the product molecular weight 397.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.58 mL	25.16 mL
5 mM	0.50 mL	2.52 mL	5.03 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for Xamoterol hemifumarate

References are publications that support the biological activity of the product.

Malta The in vitro pharmacology of xamoterol (ICI 118,587). Br.J.Pharmacol. 1985 PMID: 2862938
Nuttall and Snow The cardiovascular effects of ICI 118,587: a β₁-adrenoceptor partial agonist. Br.J.Pharmacol. 1982 PMID: 6128041
Barlow β-Adrenoceptor stimulant properties of aminoalkylamino-substituted 1-aryl-2-ethanols and 1-(aryloxy)-2-propanols. J.Med.Chem. 1981 PMID: 6115058