Xanthohumol

Name: Xanthohumol
Brand: Tocris Bioscience
SKU: 4686

Tocris Bioscience, part of Bio-Techne | Catalog # 4686

Citations (4)

COA / SDS

p97 ATPase (VCP) inhibitor

Key Product Details

Chemical Name:	(2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
Purity:	≥98%

View Full Technical Details for Xanthohumol

Technical Data
Citations

Biological Activity for Xanthohumol

Xanthohumol is a p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC₅₀ = 50.3 μM).

Technical Data for Xanthohumol

Formula	C₂₁H₂₂O₅
Storage	Store at +4°C
Purity	≥98%
CAS Number	6754-58-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Xanthohumol

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Xanthohumol

References are publications that support the biological activity of the product.

Sasazawa et al. Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein. ACS Chem.Biol., 2012;7:892 PMID: 22360440
Tabata et al. Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry, 1997;46:683 PMID: 9366096
Inokoshi et al. Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. J.Antibiot.(Tokyo), 2009;62:51 PMID: 19132064

Xanthohumol

Tocris Bioscience, part of Bio-Techne | Catalog # 4686

Key Product Details

Biological Activity for Xanthohumol

Technical Data for Xanthohumol

Solubility for Xanthohumol

Dilution Calculator

Reconstitution Calculator

References for Xanthohumol

Product Documents for Xanthohumol

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected