XAP 044

Name: XAP 044
Brand: Tocris Bioscience
SKU: 5248

Tocris Bioscience, part of Bio-Techne | Catalog # 5248

(1)

Citations (3)

COA / SDS

Potent and selective mGlu7 antagonist

Key Product Details

Chemical Name:	7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for XAP 044

XAP 044 is a potent and selective mGlu₇ antagonist (IC₅₀ = 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu₇ deficient mice. Exhibits novel activity by binding to the mGlu₇ Venus flytrap domain (VFTD). Exhibits anti-anxiety effects in rodent models. Brain penetrant.

Technical Data for XAP 044

Formula	C₁₅H₉IO₄
Storage	Store at -20°C
Purity	≥98%
CAS Number	196928-50-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for XAP 044

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in ethanol

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References for XAP 044

References are publications that support the biological activity of the product.

Gee et al. Blocking metabotropic glutamate receptor subtype 7 (mGlu₇) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J.Biol.Chem., 2014;289:10975 PMID: 24596089

XAP 044

Tocris Bioscience, part of Bio-Techne | Catalog # 5248

Key Product Details

Biological Activity for XAP 044

Technical Data for XAP 044

Solubility for XAP 044

Dilution Calculator

Reconstitution Calculator

References for XAP 044

Product Documents for XAP 044

COA

Certificate of Analysis

SDS

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