XL 184

Tocris Bioscience, part of Bio-Techne | Catalog # 5422

COA / SDS

Potent VEGFR inhibitor; also inhibits other RTKs

Key Product Details

Chemical Name:	N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for XL 184

XL 184 is a potent VEGFR inhibitor (IC₅₀ = 0.035 nM); also inhibits c-Met, KIT, RET, FLT4, AXL, FLT3, FLT1 and Tie2 (IC₅₀ values are 1.3, 4.6, 5.2, 6, 7, 11.3, 12 and 14.3 nM, respectively). Induces intratumoral hypoxia and apoptosis. Reduces tumor invasion and metastasis in vivo. Antiangiogenic.

Technical Data for XL 184

Formula	C₂₈H₂₄FN₃O₅
Storage	Store at +4°C
Purity	≥98%
CAS Number	849217-68-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for XL 184

Solubility

Soluble Soluble to 100 mM in DMSO

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References for XL 184

References are publications that support the biological activity of the product.

You et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res., 2012;71:4758 PMID: 21613405
Yakes et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol.Cancer Ther., 2011;10:2298 PMID: 21926191

XL 184

Tocris Bioscience, part of Bio-Techne | Catalog # 5422

Key Product Details

Biological Activity for XL 184

Technical Data for XL 184

Solubility for XL 184

Dilution Calculator

Reconstitution Calculator

References for XL 184

Product Documents for XL 184

COA

Certificate of Analysis

SDS

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