YC 1

Biological Activity for YC 1

Technical Data for YC 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YC 1

References for YC 1

References are publications that support the biological activity of the product.

• Ko et al. YC-1, a novel activator of platelet guanylate cyclase. Blood., 1994;84:4226 PMID: 7527671
• Martin et al. YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components. Proc.Natl.Sci.U.S.A., 2001;98:12938 PMID: 11687640
• Wang et al. YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells. J.Pharmacol.Exp.Ther., 2005;312:917 PMID: 15525795
• Teixeira et al. Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4 J.Pharmacol.Exp.Ther., 2006;317:258 PMID: 16352702