YC 1

Name: YC 1
Brand: Tocris Bioscience
SKU: 4307

Tocris Bioscience, part of Bio-Techne | Catalog # 4307

Citations (7)

COA / SDS

Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest

Key Product Details

Description:	Soluble guanylyl cyclase (sGC) activator; induces G₁ cell cycle arrest
Chemical Name:	3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole
Purity:	≥99% (HPLC)
Molecular Weight:	304.34

View Full Technical Details for YC 1

Technical Data
Citations

Biological Activity for YC 1

YC 1 is a nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC₅₀ = 14.6 μM); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC₅₀ = 1.9 μM). Also displays antiproliferative activity in vitro and in vivo by inducing G₁ cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.

Compound Libraries for YC 1

YC 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for YC 1

M. Wt	304.34
Formula	C₁₉H₁₆N₂O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	170632-47-0
PubChem ID	5712
InChi Key	OQQVFCKUDYMWGV-UHFFFAOYSA-N
Smiles	OCC4=CC=C(O4)C2=NN(CC3=CC=CC=C3)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YC 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.43	100
	ethanol	15.22	50

Preparing Stock Solutions for YC 1

The following data is based on the product molecular weight 304.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.29 mL	16.43 mL	32.86 mL
5 mM	0.66 mL	3.29 mL	6.57 mL
10 mM	0.33 mL	1.64 mL	3.29 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for YC 1

References are publications that support the biological activity of the product.

Teixeira Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4 J.Pharmacol.Exp.Ther. 2006 PMID: 16352702
Martin YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components. Proc.Natl.Sci.U.S.A. 2001 PMID: 11687640
Wang YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells. J.Pharmacol.Exp.Ther. 2005 PMID: 15525795
Ko YC-1, a novel activator of platelet guanylate cyclase. Blood. 1994 PMID: 7527671