YM 155

Name: YM 155
Brand: Tocris Bioscience
SKU: 6491

Tocris Bioscience, part of Bio-Techne | Catalog # 6491

Citations (6)

COA / SDS

Survivin suppressor

Key Product Details

Description:	Survivin suppressor
Alternative Names:	sepantronium bromide
Chemical Name:	4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide
Purity:	≥98% (HPLC)
Molecular Weight:	443.29

View Full Technical Details for YM 155

Technical Data
Citations

Biological Activity for YM 155

YM 155 is a survivin suppressor. Down-regulates survivin expression and sensitizes human NSCLC cell lines to radiation. Enhances radiation-induced tumor regression in nude mice bearing NSCLC xenografts. Also induces apoptosis in TRAIL-resistant glioma cells in vitro. YM 155 is also an inhibitor of ILF3 (interleukin enhancer binding factor 3), an RNA-binding protein. It reduces thermal and mechanical hypersensitivity in a mice model of inflammatory pain.

Compound Libraries for YM 155

YM 155 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for YM 155

M. Wt	443.29
Formula	C₂₀H₁₉BrN₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	781661-94-7
PubChem ID	46931000
InChi Key	OOLCTHGNPMKPRV-UHFFFAOYSA-M
Smiles	COCCN1C(C)=[N+](C2=C1C(C3=CC=CC=C3C2=O)=O)CC4=NC=CN=C4.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YM 155

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	44.33	100
	DMSO	8.87	20

Preparing Stock Solutions for YM 155

The following data is based on the product molecular weight 443.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.28 mL	22.56 mL
5 mM	0.45 mL	2.26 mL	4.51 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for YM 155

References are publications that support the biological activity of the product.

Premkumar Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway. J.Pharmacol.Exp.Ther. 2013 PMID: 23740602
Serafini SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model. Sci.Signal. 2023 PMID: 37159520
Iwasa Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin.Cancer Res. 2008 PMID: 18927289