Zacopride hydrochloride

Name: Zacopride hydrochloride
Brand: Tocris Bioscience
SKU: 1795

Tocris Bioscience, part of Bio-Techne | Catalog # 1795

Citations (5)

COA / SDS

Highly potent 5-HT3 antagonist; also 5-HT4 agonist

Key Product Details

Description:	Highly potent 5-HT₃ antagonist; also 5-HT₄ agonist
Chemical Name:	(±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	346.26

View Full Technical Details for Zacopride hydrochloride

Technical Data
Citations

Biological Activity for Zacopride hydrochloride

Zacopride hydrochloride is a highly potent 5-HT₃ receptor antagonist (K_i = 0.38 nM) and 5-HT₄ receptor agonist (K_i = 373 nM). Antiemetic and anxiolytic following systemic administration in vivo.

Compound Libraries for Zacopride hydrochloride

Zacopride hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Zacopride hydrochloride

M. Wt	346.26
Formula	C₁₅H₂₀ClN₃O₂.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	101303-98-4
PubChem ID	9928181
InChi Key	ITXVOUSORXSTQH-UHFFFAOYSA-N
Smiles	Cl.COC1=C(C=C(Cl)C(N)=C1)C(=O)NC1CN2CCC1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Zacopride hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	34.63	100
	DMSO	34.62	100

Preparing Stock Solutions for Zacopride hydrochloride

The following data is based on the product molecular weight 346.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.89 mL	14.44 mL	28.88 mL
5 mM	0.58 mL	2.89 mL	5.78 mL
10 mM	0.29 mL	1.44 mL	2.89 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for Zacopride hydrochloride

References are publications that support the biological activity of the product.

Nagakura Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT₄ receptor versus human 5-HT₃ receptor. Pharmacol.Res. 1999 PMID: 10328995
Costall Zacopride: anxiolytic profile in rodent and primate models of anxiety. J.Pharm.Pharmacol. 1988 PMID: 2900320
Kii and Ito Effects of 5-HT₄-receptor agonists, cisapride, mosapride citrate, and zacopride, on cardiac action potentials in guinea pig isolated papillary muscles. J.Cardiovasc.Pharmacol. 1997 PMID: 9213211
Cohen Comparison of the 5-HT₃ receptor antagonist properties of ICS 205-930, GR38032F and zacopride. J.Pharmacol.Exp.Ther. 1989 PMID: 2521513