ZE 132

Name: ZE 132
Brand: Tocris Bioscience
SKU: 7533

Tocris Bioscience, part of Bio-Techne | Catalog # 7533

COA / SDS

Potent and selective PD-1/PD-L1 interaction inhibitor

Key Product Details

Description:	Potent and selective PD-1/PD-L1 interaction inhibitor
Chemical Name:	2-[[[5-Chloro-2-[(5-cyano-3-pyridinyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl][3-(dimethylamino)propyl]amino]ethanesulfonic acid
Purity:	≥98% (HPLC)
Molecular Weight:	721.27

View Full Technical Details for ZE 132

Technical Data
Citations

Biological Activity for ZE 132

ZE 132 binds to programmed cell death-ligand 1 (PD-L1) with high affinity (K_D= 19.36 nM); it potently and selectively inhibits the interaction between programmed cell death-1 (PD-1) and PD-L1 (IC₅₀ = 23.49 nM). ZE 132 promotes CD8⁺ T cell activation and improves the in vitro cytotoxic killing activity of T-cells. ZE 132 treatment can increase Cxcl9 mRNA expression and lower Tgfb1 mRNA expression in CT26 mouse colorectal cancer model. ZE 132 shows antitumor effects, inhibiting growth of CT26 tumors in mice by 64%.

Technical Data for ZE 132

M. Wt	721.27
Formula	C₃₇H₄₁ClN₄O₇S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2566710-63-0
PubChem ID	155367962
InChi Key	QJSJWFVBDAPNAE-UHFFFAOYSA-N
Smiles	CN(CCCN(CC1=C(C=C(C(Cl)=C1)OCC2=CC=CC(C3=CC=C4OCCOC4=C3)=C2C)OCC5=CN=CC(C#N)=C5)CCS(O)(=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZE 132

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	72.13	100

Preparing Stock Solutions for ZE 132

The following data is based on the product molecular weight 721.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.39 mL	6.93 mL	13.86 mL
5 mM	0.28 mL	1.39 mL	2.77 mL
10 mM	0.14 mL	0.69 mL	1.39 mL
50 mM	0.03 mL	0.14 mL	0.28 mL

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References for ZE 132

References are publications that support the biological activity of the product.

Liu Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy. Br.J.Pharmacol. 2021 PMID: 33768523