ZIP

Name: ZIP
Brand: Tocris Bioscience
SKU: 2549

Tocris Bioscience, part of Bio-Techne | Catalog # 2549

Citations (9)

COA / SDS

Cell-permeable inhibitor of atypical PKC isozyme PKMζ

Key Product Details

Description:	Cell-permeable inhibitor of atypical PKC isozyme PKMζ
Alternative Names:	z-Pseudosubstrate inhibitory peptide
Purity:	≥95% (HPLC)
Molecular Weight:	1928.4

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Technical Data
Citations

Biological Activity for ZIP

ZIP is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC₅₀ = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

Control Peptide and Biotinylated Peptide also available.

Technical Data for ZIP

M. Wt	1928.4
Formula	C₉₀H₁₅₄N₃₀O₁₇
Single Letter Sequence	SIYRRGARRWRKL (Modifications: Ser-1 = Myr-Ser)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	863987-12-6
PubChem ID	16156119
InChi Key	CRKARHQCXWSUMV-HOHDCHNJSA-N
Smiles	[H]N([C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZIP

Solubility

Soluble to 1mg/ml in water

Molarity Calculator

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References for ZIP

References are publications that support the biological activity of the product.

Pastalkova Storage of spatial information by the maintenance mechanism of LTP. Science 2006 PMID: 16931766
Ling Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci.
Serrano Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 2005 PMID: 15728837

ZIP

Tocris Bioscience, part of Bio-Techne | Catalog # 2549

Key Product Details

Biological Activity for ZIP

Technical Data for ZIP

Solubility for ZIP

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ZIP

Product Documents for ZIP

COA

Certificate of Analysis

SDS

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