ZK 200775

Name: ZK 200775
Brand: Tocris Bioscience
SKU: 2345

Tocris Bioscience, part of Bio-Techne | Catalog # 2345

Citations (12)

COA / SDS

Competitive non-NMDA iGluR antagonist

Key Product Details

Chemical Name:	[[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]phosphonic acid
Purity:	≥99%
Molecular Weight:	409.25 kDa

View Full Technical Details for ZK 200775

Technical Data
Citations

Biological Activity for ZK 200775

ZK 200775 is a competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [³H]-AMPA (K_i = 120 nM) and [³H]-CNQX (K_i = 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC₅₀ values range from 2.5 to 11 μM). Inhibits currents induced by AMPA, Kainate and NMDA with IC₅₀ values of 21 nM, 27 nM, and > 1 μM respectively. Displays anxiolytic, anticonvulsant and muscle relaxant activity in vivo.

Technical Data for ZK 200775

M. Wt	409.25 kDa
Formula	C₁₄H₁₅N₃O₆F₃P
Storage	Desiccate at +4°C
Purity	≥99%
CAS Number	161605-73-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZK 200775

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in ethanol

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References for ZK 200775

References are publications that support the biological activity of the product.

Sobolevsky X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature, 2009;462:745 PMID: 19946266
Elger et al. Novel α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor antagonists of 2,3-benzodiazepine type: chemical synthesis, in vitro characterization, and in vivo prevention of acute neurodegeneration. J.Med.Chem., 2005;48:4618 PMID: 15999999
Turski et al. ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauman Proc.Natl.Acad.Sci.USA., 1998;95:10960
Kosowski et al. Nicotine-induced DA release in the nucleus accumbens is inhibited by the novel AMPA antagonist ZK200775 and the NMDA antagonist CGP39551n Pychopharmacology, 2004;175:114