ZM 447439

Name: ZM 447439
Brand: Tocris Bioscience
SKU: 2458
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2458

(1)

Citations (182)

COA / SDS

Inhibits Aurora kinase B

Key Product Details

Description:	Inhibits Aurora kinase B
Chemical Name:	N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	513.59

View Full Technical Details for ZM 447439

Technical Data
Citations / Reviews (1)

Biological Activity for ZM 447439

ZM 447439 is a novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC₅₀ values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC₅₀ > 10 μM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for ZM 447439

ZM 447439 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for ZM 447439

M. Wt	513.59
Formula	C₂₉H₃₁N₅O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	331771-20-1
PubChem ID	9914412
InChi Key	OGNYUTNQZVRGMN-UHFFFAOYSA-N
Smiles	COC1=CC2=C(NC3=CC=C(NC(=O)C4=CC=CC=C4)C=C3)N=CN=C2C=C1OCCCN1CCOCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZM 447439

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	51.36	100

Preparing Stock Solutions for ZM 447439

The following data is based on the product molecular weight 513.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.74 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for ZM 447439

References are publications that support the biological activity of the product.

Jung Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. J.Med.Chem. 2006 PMID: 16451062
Girdler Validating Aurora B as an anti-cancer drug target. J.Cell Sci. 2006 PMID: 16912073
Ditchfield Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J.Cell Biol. 2003 PMID: 12719470