Zoledronic Acid

Name: Zoledronic Acid
Brand: Tocris Bioscience
SKU: 6111

Tocris Bioscience, part of Bio-Techne | Catalog # 6111

Citations (2)

COA / SDS

Potent farnesyl diphosphate (FPP) synthase inhibitor

Key Product Details

Description:	Potent farnesyl diphosphate (FPP) synthase inhibitor
Alternative Names:	Zometa
Chemical Name:	[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid
Purity:	≥98% (HPLC)
Molecular Weight:	272.09

View Full Technical Details for Zoledronic Acid

Technical Data
Citations

Biological Activity for Zoledronic Acid

Zoledronic Acid is a potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC₅₀ = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.

Technical Data for Zoledronic Acid

M. Wt	272.09
Formula	C₅H₁₀N₂O₇P₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	118072-93-8
PubChem ID	68740
InChi Key	XRASPMIURGNCCH-UHFFFAOYSA-N
Smiles	OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Zoledronic Acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1.1eq. NaOH	13.6	50
	water	0.68	2.5

Preparing Stock Solutions for Zoledronic Acid

The following data is based on the product molecular weight 272.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.35 mL	36.75 mL	73.51 mL
2.5 mM	1.47 mL	7.35 mL	14.70 mL
5 mM	0.74 mL	3.68 mL	7.35 mL
25 mM	0.15 mL	0.74 mL	1.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Zoledronic Acid

References are publications that support the biological activity of the product.

Tassone Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. Br.J.Cancer 2003 PMID: 12799645
Dunford Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J.Pharmacol.Exp.Ther. 2001 PMID: 11160603
Schech Zoledronic acid reverses the epithelial-mesenchymal transition and inhibits self-renewal of breast cancer cells through inactivation of NF-κB. Mol.Cancer Ther. 2013 PMID: 23619300