ZQ 16

Name: ZQ 16
Brand: Tocris Bioscience
SKU: 6001

Tocris Bioscience, part of Bio-Techne | Catalog # 6001

Citations (22)

COA / SDS

Selective GPR84 agonist

Discontinued Product

6001 has been discontinued. View all Free Fatty Acid Receptor Agonists products.

Key Product Details

Description:	Selective GPR84 agonist
Chemical Name:	2-(Hexylthio)-6-hydroxy-4(3H)-pyrimidinone
Purity:	≥98% (HPLC)
Molecular Weight:	228.31

View Full Technical Details for ZQ 16

Technical Data
Citations

Biological Activity for ZQ 16

ZQ 16 is a selective medium-chain free fatty acid receptor GPR84 agonist (EC₅₀ = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro.

Technical Data for ZQ 16

M. Wt	228.31
Formula	C₁₀H₁₆N₂O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	376616-73-8
PubChem ID	1912564
InChi Key	UYXOAKRMLQKLQX-UHFFFAOYSA-N
Smiles	CCCCCCSC1=NC(O)=CC(N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ZQ 16

References are publications that support the biological activity of the product.

Zhang Discovery and characterization of a novel small-molecule agonist for medium-chain free fatty acid receptor G protein-coupled receptor 84. J.Pharmacol.Exp.Ther. 2016 PMID: 26962172
Liu Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists. ACS Med.Chem.Lett. 2016 PMID: 27326330

ZQ 16

Tocris Bioscience, part of Bio-Techne | Catalog # 6001

Key Product Details

Biological Activity for ZQ 16

Technical Data for ZQ 16

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ZQ 16

Product Documents for ZQ 16

COA

Certificate of Analysis

SDS

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