DLin-MC3-DMA

Name: DLin-MC3-DMA
Brand: Tocris Bioscience
SKU: 7946

Tocris Bioscience, part of Bio-Techne | Catalog # 7946

COA / SDS

Component of lipid nanoparticles (LNPs); ionizable cationic lipid

Key Product Details

Description:	Component of lipid nanoparticles (LNPs); ionizable cationic lipid
Chemical Name:	(6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate
Purity:	≥95% (HPLC)
Molecular Weight:	642.09

View Full Technical Details for DLin-MC3-DMA

Technical Data
Citations

Biological Activity for DLin-MC3-DMA

DLin-MC3-DMA is an ionizable cationic lipid (pK_a = 6.44), used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for delivering cargos such as oligonucleotides into living cells. DLin-MC3-DMA can protect negatively charged cargos and facilitate their cytosolic transport.

For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.

Technical Data for DLin-MC3-DMA

M. Wt	642.09
Formula	C₄₃H₇₉NO₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1224606-06-7
InChi Key	NRLNQCOGCKAESA-KWXKLSQISA-N
Smiles	C(OC(CCCN(C)C)=O)(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DLin-MC3-DMA

Solubility

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 100mg/mL)

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References for DLin-MC3-DMA

References are publications that support the biological activity of the product.

Semple Rational design of cationic lipids for siRNA delivery. Nat.Biotechnol 2010 PMID: 20081866
Jayaraman Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angew.Chem.Int.Ed.Engl 2012 PMID: 22782619
Han An ionizable lipid toolbox for RNA delivery. Nat.Commun 2021 PMID: 34903741