DMG-PEG 2000

Name: DMG-PEG 2000
Brand: Tocris Bioscience
SKU: 7944

Tocris Bioscience, part of Bio-Techne | Catalog # 7944

COA / SDS

PEGylated myristoyl diglyceride; commonly used in the formation of lipid nanoparticles (LNPs)

Key Product Details

Description:	PEGylated myristoyl diglyceride; commonly used in the formation of lipid nanoparticles (LNPs)
Chemical Name:	1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000
Purity:	≥90% (HPLC)

View Full Technical Details for DMG-PEG 2000

Technical Data
Citations

Biological Activity for DMG-PEG 2000

DMG-PEG 2000 is a PEGylated myristoyl diglyceride consisting of one unbranched PEG 2000 chain and two saturated fatty acid chains (C14:0) covalently attached to a glycerol. DMG-PEG 2000 is commonly used in the formation of lipid nanoparticles (LNPs) and liposomes to prevent serum protein adsorption, nanoparticle aggregation and increase in vivo circulation time. DMG-PEG 2000 is a component of LNPs which can be used for delivery of RNA-based vaccines or mRNA therapeutics.

For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.

Technical Data for DMG-PEG 2000

Formula	(C₂H₄O)_nC₃₂H₆₂O₅
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	160743-62-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DMG-PEG 2000

Solubility

Soluble to 10mg/ml in ethanol and to 10mg/ml in chloroform

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References for DMG-PEG 2000

References are publications that support the biological activity of the product.

Zhang Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing. Sci.Adv. 2020 PMID: 32937374
Cheng Dendrimer-based lipid nanoparticles deliver therapeutic FAH mRNA to normalize liver function and extend survival in a mouse model of hepatorenal tyrosinemia type I. Adv.Mater. 2018 PMID: 30368954

DMG-PEG 2000

Tocris Bioscience, part of Bio-Techne | Catalog # 7944

Key Product Details

Biological Activity for DMG-PEG 2000

Technical Data for DMG-PEG 2000

Solubility for DMG-PEG 2000

Dilution Calculator

Reconstitution Calculator

References for DMG-PEG 2000

Product Documents for DMG-PEG 2000

COA

Certificate of Analysis

SDS

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