DSPE-PEG 2000 Maleimide

Name: DSPE-PEG 2000 Maleimide
Brand: Tocris Bioscience
SKU: 7947

Tocris Bioscience, part of Bio-Techne | Catalog # 7947

COA / SDS

PEGylated DSPE with a maleimide reactive group

Key Product Details

Description:	PEGylated DSPE with a maleimide reactive group
Chemical Name:	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol-2000)]
Purity:	≥90% (HPLC)

View Full Technical Details for DSPE-PEG 2000 Maleimide

Technical Data
Citations

Biological Activity for DSPE-PEG 2000 Maleimide

DSPE-PEG 2000 Maleimide is a functionalized phospholipid-polymer conjugate. It comprises a 1,2-distearoyl-sn-glycero-PE (DSPE) covalently coupled to a linear polyethylene glycol (M_r 2000) with a maleimide-terminated end for onward chemistry. It is commonly used to synthesize antibody-coupled liposomes and lipid nanoparticles. It has been used in antibody-targeted LNP-mRNA systems to generate transient antifibrotic chimeric antigen receptor (CAR) T cells in vivo.

Technical Data for DSPE-PEG 2000 Maleimide

Formula	(C₂H₄O)_nC₅₁H₉₁N₃O₁₃P.NH₄ or Na
Storage	Store at -20°C
Purity	≥90% (HPLC)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DSPE-PEG 2000 Maleimide

Solubility

Soluble to 10mg/ml in ethanol with gentle warming and to 10mg/ml in chloroform

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References for DSPE-PEG 2000 Maleimide

References are publications that support the biological activity of the product.

Rurik CAR T cells produced in vivo to treat cardiac injury. Science 2022 PMID: 34990237
Herrera-Barrera Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates. Sci.Adv. 2023 PMID: 36630502
Ishida A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs. FEBS Lett. 1999 PMID: 10571074

DSPE-PEG 2000 Maleimide

Tocris Bioscience, part of Bio-Techne | Catalog # 7947

Key Product Details

Biological Activity for DSPE-PEG 2000 Maleimide

Technical Data for DSPE-PEG 2000 Maleimide

Solubility for DSPE-PEG 2000 Maleimide

Dilution Calculator

Reconstitution Calculator

References for DSPE-PEG 2000 Maleimide

Product Documents for DSPE-PEG 2000 Maleimide

COA

Certificate of Analysis

SDS

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