Tools for Models Systems Research
Animal model systems are used as a substitute for humans, or other animals, to generate answers offered by in vivo testing in a complex living system. The two main classes of models include analogy (similar structures, similar functions, useful answers), and homology (structures that have similar function based of evolutionary traits).1
Bio-Techne’s high quality products are suitable for in vivo work and provide a lower risk of experiments failing. As research progresses through model systems from single cell organisms to multi-cellular to complex mammalian models, researchers need to consider both higher quality and scale.
The remarkable anatomical and physiological similarities between humans and animals, particularly mammals, have prompted researchers to investigate a large range of mechanisms and assess novel therapies in animal models before applying their discoveries to humans.2
Careful consideration is needed to design experiments using the most appropriate platform, study design, and screening methods. 3 Bio-Techne reagents and services are available to support vaccine research, cell therapies, Patient-Derived Xenograft Models, Syngeneic Models, Humanized Models, and more.
Industry-Leading Proteins
Over 40 years of protein manufacturing knowledge and experience enables us to be first to market in new areas, as with our range of avi-tagged proteins and new proteins for COVID-19 research.
Unbeatable Biological Activity
Our scientists go the extra mile to develop proteins of the highest quality for your business.
- Methods to guarantee accurate protein folding ensure that our proteins are biologically relevant
- Over 2000 different bioactivity assays performed on our catalog proteins, we provide the most accurate and relevant activity data for your protein of interest
High Lot-to-lot Consistency and bioactivity of Human R-Spondin 1. Three independent lots of Recombinant Human R-Spondin 1 (R&D Systems, Catalog # 4645-RS) were tested for their ability to stimulate activation of beta-Catenin using a TOPflash beta-Catenin/TCF reporter assay in the HEK293T human kidney cell line, in the presence of 5 ng/mL Recombinant Mouse Wnt-3a (R&D Systems, Catalog # 1324-WN). Each trace represents data obtained from Recombinant Human R-Spondin 1 from a different manufacturing run.
Quality and Consistency Time After Time
We know that our partners need dependable products that deliver reproducible results, time after time. By investing in a Bio-Techne protein, you benefit from our rigorous quality control processes.
Extensive Quality Control
Our QC measures include lot specific Certificates of Analysis, dedicated manufacturing space, monitoring of product stability over shelf life and transparent traceability of raw materials.
Lot-to-Lot Consistency
Each new product lot is tested side-by-side with previous lots for purity, biological activity, and endotoxin level. We also routinely test a sample from an earlier lot to control for variability in the assay itself.
Low Endotoxin And Microbial Bioburden
Each new production lot is assessed for endotoxin using the LAL assay to ensure levels as low as <0.01 EU/ug. Microbial contamination is ruled out using both direct plating and broth dilution.
Accurate Proteins Sequences
N-terminal amino acid sequence analysis is performed for every recombinant protein we develop.
Buffer Systems
We take great care that our proteins are made, stored and shipped in physiologically relevant buffers for optimal bioactivity.
Your Business, Our Support
Harness Over 40 Years of Protein Manufacturing Expertise When You Choose Bio-Techne as a Partner
“Through R&D Systems, Bio-Techne has a long history of providing our customers with the highest quality proteins on the market. Our team of scientists are dedicated to utilizing our cutting-edge expression and purification procedures to give our customers the best proteins available. We offer extensive analytical capabilities and bioassay services to ensure a protein has the physical characteristics and bioactivity that our customers require.”
Anthony Person, PH.D.
Sr. Director of Protein Development, R&D Systems
Fluorescent Probes and Dyes
Fluorescent Probes and Dyes
Tocris offers a broad range of fluorescent and bioluminescent reagents, to facilitate the visualization of sub-cellular components in live and fixed cells with high sensitivity and selectivity and to follow proteins and compounds in vivo with near-infrared imaging fluorophores.
Cynomolgus Monkey Proteins and Enzyme
Cynomolgus Monkey Proteins and Enzyme
R&D Systems offers an expanding line of Recombinant Cynomolgus Monkey proteins and Rhesus Macaque proteins. Because of the high degree of genetic similarity to humans, cynomolgus monkey is a popular model of choice for immunotherapy researchers interested in the field of checkpoint immunology. They are also used in toxicology and drug efficacy studies by the pharmaceutical industry.
Bulk Quote Form
Bulk Quote Form
Bio-Techne offers competitive discounts on bulk quantities of our Recombinant Proteins, Antibodies, Assays and Small Molecules as either individual or
multiple items.
Custom Protein Services
Custom Protein Services
Proteins Designed to Meet Your Specific Research Needs
Your research may depend on sourcing unique proteins or specialized protein solutions, our Custom Protein Services team is here to assist you. We can also facilitate the specialized bottling if that is what your project needs.
GMP Capabilities
GMP Capabilities
What is the end goal of your research? Good Manufacturing Practices are key to successful Cell & Gene Therapy programs. We can reduce your manufacturing risks by providing industry-leading quality, consistency, reliability, and capacity.
References
- Aaron C Ericsson 1, Marcus J Crim, Craig L Franklin A brief history of animal modeling. Mo Med. May-Jun 2013;110(3):201-5. https://pubmed.ncbi.nlm.nih.gov/23829102/
- Françoise Barré-Sinoussi 1 and Xavier Montagutelli* 2 Animal models are essential to biological research: issues and perspectives Future Sci OA. 2015 Nov; 1(4): FSO63. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137861/
- Lipinski C, Hopkins A (December 2004). "Navigating chemical space for biology and medicine". Nature. 432 (7019): 855–61. https://www.nature.com/articles/nature03193