Angiogenesis in Cancer Product Guide

Angiogenesis describes the generation of new blood vessels from pre-existing vasculature. This is a normal process in growth and development, being required for the formation of arteries, veins, and capillaries. Proliferation of new blood vessels has an essential role for the repair and regeneration of tissue during wound healing, muscle growth, embryonic development, and in the menstrual cycle.

Angiogenesis is also a hallmark of cancer and plays a key role in tumor growth, progression, and metastasis. Tumor angiogenesis can differ significantly from physiological angiogenesis, producing poorly formed blood vessels with aberrant blood flow and different permeability. It is a complex and dynamic process which involves various signaling pathways and biomolecules that promote or inhibit this mechanism.

This product guide provides a background to angiogenesis in cancer and highlights products that can be used to investigate angiogenesis therapeutic targets including:

• Growth Factors
• Transcription Factors
• Adhesion, Extracellular Matrix Remodeling
• Key Signaling Pathways